Clinical Trial of Shirodhara in Chittodvega Vis-À-Vis Generalized Anxiety Disorders

 

Ajay Saxena1*, P.K. Rai2, Ajay Meena1, Anupam Srivastava1, Kiran Srivastava3, Priyanka Pandey4

1Department of AYUSH, New Delhi - 110023

2CCIM, Janakpuri,  New Delhi – 110058

3Dravyaguna Department, Kanpur University, Kanpur (UP)

4CGHS, Wellness Center, Devnagar, New Delhi.

*Corresponding Author E-mail:

 


INTRODUCTION:

Ayurveda is the science of life. Acharya Charak has mentioned the characteristics of aayu as-

 

 

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There are two types of doshas in our body responsible for various activities- Shariradoshas (Vata, Pitta, Kapha); ManasDoshas (Satva, Rajas, Tamas). Usually, sharira and manasikadoshas are interrelated with each other, hence the concept of pschychosomatic disorder is well accepted in ayurveda. of the three humorsVata (especially Prana, Vyana and Udana Vata) is mainly responsible for the activities of the mind i.e. it is the controller and stimulator of mind and is responsible for enthusiasm. Sadhaka Pitta is directly related to the function of mind.

It is responsible for intelligence, memory and intellect, self-esteem, enthusiasm .Kapha (Tarpaka and Bodhaka Kapha) is responsible for  patience, courage, knowledge, learning, wisdom, cognition, perception, comprehensiveness, understanding, talent, greedlessness, stability, enthusiasm, etc.

 

 

Chittodvega can be defined as a Chitta (mind) + Udvega (anxiety) =Chittodvega –‘Anxious status of a mind”. In Charakavimana 6 (Rogaanikvimaanaadhyaya) Chittodvega is considered as raja-tama vikara-

 

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SAMPRAPTI CHART OF MANASIKA ROGA (CHITTODVEGA):

 

ASAATMYENDRIYARTHASAMYOGA     PRAJNAAPARAADHA                   PARINAAMA

                                                                                                        

 

 

 

 

                                                                       

 

 

                                                                          DOSHAS PRAKOPA

 

                                                                                         

                                                                                                                                                                            

 

SHARIRA VATADI DOSHAS                                                                             MANASIK RAJAS-TAMA DOSHAS

                                                                                                                                                                            

 

AGNI VAISHAMYA                                                                                                                   HRIDAYA DUSHTI

                                                                                                                                                                            

 

RASADI DHATU and SAVASROTO DUSHTI                                        MANAS and MANOVAHASROTO DUSHTI

                                                                                                                                                                            

 

SHARIRIKA SYMPTOMS APPEAR                                                                  MANASIKA SYMPTOMS APPEAR

                                                                                                                                                                            

 

 

MANASIK ROGA (CHITTODVEGA)

 

 


Site of manas is both Hridaya and Mastiska (Brain)

SampraptiGhataka:

1.      Dosha  Manasa– Raja, Tama

        ShariraVata Prana, Udana and Vyana;

        PittaSadhaka;

        KaphaTarpaka;

2.     DusyaMana, Rasadidhatu;

3.     Agni– JatharagniManda, Visama;

4.     SrotasManovaha, Sarvasrotodusti;

5.     Udbhava Sthana- Hridaya; Mastishka

6.     Vyakti SthanaMana; (Hridaya and Mastishka)

 

Sarva Sariravikara:

Acarya Charaka has explained three types of therapies of physical and mental disorders:

1. Daivavyapasraya– Spiritual therapy

2. Yuktivyapasrya – Physical therapy

3. Sattvavajaya      – Psychological therapy.(Cha.Su. 11/54)

 

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This is one of the most common mental disordersnow a day. Patients with generalized anxiety disorder (GAD) have persistent, excessive, and/or unrealistic worry associated with muscle tension, impaired concentration, autonomic arousal, feeling "on edge" or restless, and insomnia. Onset is usually before age 20, and a history of childhood fears and social inhibition may be present. The lifetime prevalence of GAD is 5–6%; the risk is higher in first-degree relatives of patients with the diagnosis. Interestingly, family studies indicate that GAD and panic disorder segregate independently. Patients with GAD worry excessively over minor matters, with life-disrupting effects.

 

Generalized anxiety disorder:                                                       URL of

this page: http://www.nlm.nih.gov/medlineplus/ency/article/000917.htm

Generalized anxiety disorder (GAD) is a pattern of frequent, constant worry and anxietyanxiety over many different activities and events.

 

Causes:

Causes

Generalized anxiety disorder (GAD) is a common condition. Genes may play a role. Stressful life situations or learned behaviour may also contribute to the development of GAD.

 

The disorder may start at any time in life, including childhood. Most people with the disorder report that they have been anxious for as long as they can remember. GAD occurs somewhat more often in women than in men.

 

Symptoms:

Symptoms

The main symptom is the almost constant presence of worry or tension, even when there is little or no cause. Worries seem to float from one problem to another, such as family or relationship problems, work issues, money, health, and other problems.

Even when aware that their worries or fears are stronger than needed, a person with GAD still has difficulty controlling them.

Other symptoms include:

·        Difficulty concentrating

·        Fatigue

·        Irritability

·        Problems falling or staying asleep, and sleep that is often restless and unsatisfying

·        Restlessness or feeling keyed up or "on the edge," often becoming startled very easily

 

Along with the worries and anxieties, a number of physical symptoms may also be present, including muscle tension (shakiness, headaches).

 

Depression and substance abuse may occur with an anxiety disorder

 

The main Dosas of the Manasa are Raja and Tama (Ca. su. 1/57), Hence the Nidnana, which vitiate Raja and Tama may be considered as etiological factors of Chittodvega.

 

Keeping these points in view, shirodhara  (ksheerabalataila) has been used in patients of chittodvega (Generalized anxiety disorder) for 14 days

 

PATIENTS AND METHODS:

19 patients of Chittodvega were selected from O.P.D. and I.P.D. sections of Panchkarma  department of Rishikul Govt. Ay. P.G. College and Hospital, Haridwar (Uttarakhand). Detailed history and physical and mental examinations were done on the basis of specialized proforma prepared for this purpose. Pulse, respiration and blood pressure were checked to assess the present condition of the disease. Routine blood, urine and stool examinations were performed to exclude other pathogenesis. Diagnosis was done on the basis of following criteria-

 

Criteria for diagnosis:

DSM IV (Diagnostic and Statistical Manual of Mental Disorders) diagnostic criteria for various anxiety disorders were primarily adapted.

 

DSM-IV Diagnostic Criteria for Generalized Anxiety Disorder:

A. Excessive anxiety and worry (apprehensive expectation), occurring more days than not for at least 6 months, about a number of events of activities (such as work or school performance).

B. The person finds it difficult to control the worry.

C. The anxiety and worries are associated with three (or more) of the following six symptoms (with at least some symptoms present for more days than not for the past 6 months)

1. Restlessness or feeling keyed up or on edge,

2. Being easily fatigued,

3. Difficulty concentrating or mind going blank,

4. Irritability,

5. Muscle tension,

6. Sleep disturbance (difficulty falling or staying a sleep, or restless unsatisfying sleep).

 

D. The focus of the anxiety and worry is not confined to features of an Axis 1 disorder, e.g. the anxiety or worry is not about having a panic attack (as in panic disorder), being embarrassed in public (as in social phobia), being contaminated (as in obsessive – compulsive disorder), being away from home or close relatives (as in separation anxiety disorder), gaining weight (as in anorexia nervosa), having multiple physical complaints (as in somatization disorder), or having a serious illness (as in hypochondriasis), and the anxiety and worry do not occur exclusively during posttraumatic stress disorder.

 

E. The anxiety, worry or physical symptoms cause clinically significant distress or impairment is social, occupational, or other important areas of functioning.

 

F. The disturbance is not due to the direct physiological effects of a substance (e.g. a drug of abuse, a medication) or a general medical condition (e.g. hypethyroidism), and does not occur exclusively during a mood disorder, psychotic disorder, or pervasive development disorder.

 

Improvement in all the signs and symptoms as per Hamilton’s anxiety rating scale was assessed. Hamilton (1959) has described 14 types of clinical features of anxiety status, the details of which are as follows:

 

HAMILTON ANXIETY RATING SCALE:

01.    Anxious mood: Worries, anticipation of the worst, fearful anticipation, Irritability.

02.    Tension: Feeling of tension, fatigability, startles response, moved to tear easily, trembling, restlessness, inability to relax.

03.    Fears: Of dark, of strangers, of being left alone, of animals, of traffic, of crowds.

04.    Insomnia: Difficulty in falling asleep, broken sleep, unsatisfying sleep, fatigue on waking, dreams, nightmares, night terrors.

05    Intellectual (Cognitive): Difficulty in concentration, poor memory.

06    Depressed mood: Loss of interest, lack of pleasure in hobbies, depression, early waking, diurnal swing.

07    Somatic (Muscular): Pain and aches, twitching, stiffness, myoclonic jerks, grinding of teeth, unsteady voice, increased muscular tone.

08    Somatic (Sensory): Tinnitus, blurring of vision, hot and cold flushes, feeling of weakness, picking sensation.

09    Cardiovascular Symptoms: Tachycardia, palpitation, pain in chest, throbbing of vessels, fainting feelings, missing beat.

10    Respiratory Symptoms: Pressure or constriction in chest, choking feeling, sighing, dyspnoea

11    Gastrointestinal Symptoms: Difficulty in swallowing, wind, abdominal pain, burning sensation, abdominal fullness, nausea, vomiting, looseness of bowels, loss of weight, constipation.

12    Genitourinary Symptoms: Frequency of maturation, Urgency of micturation, amenorrhea, menorrhagia, development of frigidity, premature ejaculation, loss of libido, impotence.

13    Autonomic Symptoms: Dry mouth, flushing, pallor, tendency to sweat, giddiness, tension headache, raising of hair

14    Behaviour at interview: Fidgeting, restlessness or pacing, tremor of hands, furrowed brow, strained face, sighing or rapid respiration, facial pallor, swallowing, belching, brisk tendon jerks, dilated pupils, exophthalmos.

 

Signs and symptoms mentioned in Hamilton scale were assessed by adopting the following scoring system.

 

Degree of anxiety and Pathological condition Scoring:

None                                    0

Mild                                     1

Moderate                              2

Severe                                  3

Severe, grossly disabling      4

 


 

 

OBSERVATION AND RESULTS :

Effect of therapies exhibited statistically in different parameters as shown in graph-

SYMPTOMS

MEAN BT

MEAN AT

X

% RELIEF

S.D.

S.E

t

p

Anxiety

2.473

0.578

1.895

76.6

0.567

0.130

14.563

<.001

Irritability

2.157

0.526

1.631

75.61

0.760

0.174

9.3469

<.001

Tension

2.210

0.578

1.632

73.81

0.495

0.113

14.35

<.001

Fear

2.737

0.948

1.789

65.38

0.630

0.144

12.37

<.001

Insomnia

2.052

0.736

1.316

64.00

0.671

0.153

8.547

<.001

Nightmares

2.474

1.368

1.106

44.68

0.737

0.169

6.532

<.001

Memory

1.842

0.579

1.263

68.57

0.562

0.129

9.79

<.001

Lack of interest

2.105

0.579

1.526

72.50

0.687

0.159

9.549

<.001

Muscle tone

1.053

0.579

0.474

45.00

0.513

0.118

4.025

<.01

Weakness

2.315

1.737

0.578

27.17

0.830

0.191

3.314

<.01

Palpitation

2.211

1.368

0.843

38.1

0.602

0.138

6.096

<.01

Tension headache

1.842

0.737

1.105

60.00

0.737

0.169

6.532

<.001

GI disturbence

2.053

1.421

0.632

30.76

0.495

0.114

5.554

<.01

 

 


Out of 19 patients, observed % improvement in anxiety was 76.6%, its p value was <.001, i.e. highly significant; in irritability it was 75,61% and p value was <.001, i.e. highly significant; in tension it was 73.81% and p value was <.001, i.e. highly significant;  in fear it was 65.38% and p value was <.001, i.e. highly significant; in insomnia it was 64.00% and p value was <.001, i.e. highly significant;  in nightmares it was 44.68% and p value was <.001, i.e. highly significant;  in memory it was 68.57% and p value was <.001, i.e. highly significant;  in lack of interest it was 72.50% and p value was <.001, i.e. highly significant;  in muscle tone it was 45.00% and p value was <.001, i.e. highly significant;  in weakness it was 27.17% and p value was <.01, i.e.  significant;  in palpitation it was 38.1% and p value was <.01, i.e. significant; ; in tension headache it was 60.00% and p value was <.001, i.e. highly significant; ; in GI disturbance it was 30.76% and p value was <.01, i.e.  significant;     

 

DISCUSSION:

Demographic profiles of these patients didn’t show any relevancy because it is neither a community nor an age related disorder; but it was more prominent in married, retired and housewives.

 

The therapeutic trial of shirodhara (ksheerabalataila) showed beneficial effects on various symptoms as per

 

Hamilton’s Anxiety Rating Scale (HARS) as shown in above mentioned table.

 

At the site of shirodharasthapanimarma is situated. Sthapanimarma have anatomical structures like cavernous plexus, optic chiasmaand thalamus. Ajna chakra is also situated at the site of sthapanimarma. It has close relation with the hypothalamus, limbic system andneighbouring region with connections to pituitary gland. May be when shirodhara performed it stimulated these structures and produce some effect on blood pressure. The hypothalamus, major controls headquarter for limbic system. On the stimulation of different areas of the hypothalamus can cause every known type of neurogenic effect on cardiovascular system, including increase arterial pressure, decrease arterial pressure, increase heart rate and decrease heart rate. Stimulation in the posterior and lateral  hypothalamus increase the arterial pressure and heart rate, whereas stimulation in the preoptic area (sthapanimarma) has opposite effect, causing a decrease in both arterial pressure and heart rate (Guyton and Hall medical physiology 10th edition). Probably such an effect may relieve insomnia and provides mental calm, in addition to provide cure of the above mentioned symptoms. Chittodvega (Generalized Anxiety Disorder) is basically a vata predominant disorder with the involvement of raja-tama manasdoshas; ksheerabalataila has good vatashamak effect as well as it mayprovide essential nutrition to the underlying tissues. Shirodhara  is done directly on the head, so it may be considered as good for relieving the symptoms caused by stress and strain as well as other mental factors. The nidranashahara, shirorukhara, bhramahara actions shown by shirodhara indicate towards its shamaka i.e. tranquilizer effect and due to which it might reduced the blood pressure of the patients and producecalm.

 

CONCLUSION:

Anxiety symptoms are common in medically ill patients 5 to 20% of medical in patients and 4 to 14% of general medical out patients suffer from anxiety disorders, It may occur as a manifestation of a primary psychiatric disorder or secondarily to either the medical illness or the medications prescribed for treatment (Harrison).

 

Chittodvega a minor psychiatric disorder has been mentioned by Charaka (Charak Vi. 6/5), which is produced due to vitiation of Raja and Tama. In addition Prana, Udana, Vyana Vayu; Sadhaka Pitta; and Tarpaka Kapha are also provocated factors in it. Etymology of Chittodvega i.e. anxious status of mind is similar to anxiety, somatic manifestation are also same in both the condition.

 

Shirodhara therapy has been found as safe and effective treatment modalities in anxiety, irritability, inability to relax, lack of concentration, disturbed sleep, loss of memory, palpitation, headache, dryness of mouth, upset stomach and restlessness. It is having tranquilizing and anxiolytic effect resulting into a kind of relaxation response.

 

REFERENCES:

Charaka Samhita Vol. 1 and 2 by Pt. Kashinath Pandey and Dr. Gorakhnath Chaturvedi;

Panchkarma Therapy by Prof. R.H. Singh;

Astanga Hridayam Vol 1,2,3 by Dr. K. R. Srikanth Murthy;

Ayurveda Panchkarma Vigyana by VD. Kasture;

Principles of Internal Medicine by Harrison;

Kaplan and Sadock (1998): Synopsis of Psychiatry, Behavioural Sciences Clinical Psychiatry, 8th edition

Text Book of Medical Physiology by Guyton and Hall.

 

 

 

Received on 03.07.2014                             Modified on 20.07.2014

Accepted on 25.07.2014      ©A&V Publications All right reserved

Res. J. Pharmacology & P’dynamics. 6(3): July- Sept. 2014; Page 141-145